KCNH6

Across TCGA patient cohorts, KCNH6 mutation is significantly associated with the total protein of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNH6-associated genes across cancer lineages are MEK1, PCNA, and ASNS. Each is linked with KCNH6 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNH6-to-partner and partner-to-KCNH6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by KCNH6-low versus KCNH6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH6→partner) and Y-score (partner→KCNH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.266	+2.115	.019	.016	3	3
UCEC	PCNA →	+0.237	+2.169	<.001	<.001	3	3
UCEC	ASNS →	+0.274	+2.000	.014	.029	3	3
COAD	PKC-b-II_pS660 →	-0.414	-3.000	.013	.035	3	3
COAD	cIAP →	+0.121	+3.012	.043	.018	3	3
LUSC	eEF2 →	+0.238	+3.709	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

MEK1 by KCNH6 expression — UCEC

Explore this box plot interactively →