KCNH5

Across TCGA patient cohorts, KCNH5 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNH5-associated genes across cancer lineages are p70-S6K, Bim, and ATM. Each is linked with KCNH5 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNH5-to-partner and partner-to-KCNH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K grouped by KCNH5-low versus KCNH5-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH5→partner) and Y-score (partner→KCNH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	p70-S6K →	+0.324	+2.816	.015	.036	3	3
LUAD	Bim →	+0.390	+2.087	<.001	.005	3	3
UCEC	ATM →	-0.471	-1.637	<.001	.001	3	3
UCEC	Ku80 →	+0.219	+1.650	.001	<.001	3	2
UCEC	PCNA →	+0.226	+1.637	<.001	.001	3	2
UCEC	STAT3_pY705 →	-0.325	-1.392	<.001	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

p70-S6K by KCNH5 expression — LUSC

Explore this box plot interactively →