KCNH5

Across TCGA cell cohorts, KCNH5 RNA expression is significantly associated with the go_rna of many other GO terms, with 969 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible KCNH5-associated GO terms across cancer lineages are SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition, Regulation of protein K48-linked ubiquitination, and Negative regulation of intrinsic apoptotic signaling pathway. Each is linked with KCNH5 in more than 6 cancer types. Because this analysis shows association rather than direction, both KCNH5-to-partner and partner-to-KCNH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition grouped by KCNH5-low versus KCNH5-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH5→partner) and Y-score (partner→KCNH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition →	+0.076	+0.504	<.001	.002	3	7
STOMACH	Regulation of protein K48-linked ubiquitination →	+0.088	+0.325	.005	.007	3	6
LUNG_NSCLC_LUSC	Negative regulation of intrinsic apoptotic signaling pathway →	+0.060	+0.213	.006	.004	3	5
SKIN	Regulation of syncytium formation by plasma membrane fusion →	+0.050	+0.253	<.001	.004	3	5
STOMACH	Negative regulation of myoblast fusion →	+0.077	+0.376	.008	.001	3	5
CNS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.068	+0.442	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 969 associations by consensus.

SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition by KCNH5 expression — CNS

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