KCNH5

Across TCGA cell cohorts, KCNH5 mutation is significantly associated with the RNA expression of many other genes, with 724 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNH5-associated genes across cancer lineages are SEL1L2, FAM71E2, and OR2L5. Each is linked with KCNH5 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNH5-to-partner and partner-to-KCNH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEL1L2 grouped by KCNH5-low versus KCNH5-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH5→partner) and Y-score (partner→KCNH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SEL1L2 →	+0.063	+2.614	<.001	.001	3	2
SKIN	FAM71E2 →	+0.007	+2.538	.001	.005	3	2
LUNG_NSCLC_LUAD	OR2L5 →	+0.010	+3.887	<.001	.002	3	2
LUNG_NSCLC_LUAD	DCANP1 →	+0.007	+4.803	<.001	<.001	3	2
LARGE_INTESTINE	TLE6 →	+0.969	+3.584	<.001	<.001	3	2
LARGE_INTESTINE	PPP1R9A →	+1.412	+3.850	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 724 associations by consensus.

SEL1L2 by KCNH5 expression — SKIN

Explore this box plot interactively →