KCNH2

Across TCGA patient cohorts, KCNH2 mutation is significantly associated with the RNA expression of many other genes, with 4,602 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNH2-associated genes across cancer lineages are SAAL1, FANCE, and TXNRD1. Each is linked with KCNH2 in more than 4 cancer types. Because this analysis shows association rather than direction, both KCNH2-to-partner and partner-to-KCNH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAAL1 grouped by KCNH2-low versus KCNH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH2→partner) and Y-score (partner→KCNH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SAAL1 →	+0.456	+2.258	<.001	<.001	3	5
SKCM	FANCE →	+0.440	+3.112	.001	<.001	3	4
UCEC	TXNRD1 →	+0.809	+1.906	<.001	.001	3	4
SKCM	APCDD1 →	-0.978	-1.517	.005	.008	3	4
UCEC	CWC25 →	+0.382	+1.617	<.001	<.001	3	3
UCEC	ZNHIT3 →	+0.420	+1.786	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,602 associations by consensus.

SAAL1 by KCNH2 expression — UCEC

Explore this box plot interactively →