KCNH2

Across TCGA patient cohorts, KCNH2 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNH2-associated genes across cancer lineages are IRS1, Di-Ras3, and Heregulin. Each is linked with KCNH2 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNH2-to-partner and partner-to-KCNH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRS1 grouped by KCNH2-low versus KCNH2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH2→partner) and Y-score (partner→KCNH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	IRS1 →	+0.156	+3.459	.006	.005	3	3
SKCM	Di-Ras3 →	-0.160	-2.584	.002	.009	3	3
UCEC	Heregulin →	-0.082	-1.401	.027	.041	3	3
COAD	ATM →	-0.747	-2.991	<.001	.036	3	3
UCEC	Caspase-7-cleavedD198 →	+0.490	+1.300	.006	.034	3	3
UCEC	Caspase-8 →	-0.193	-2.636	.010	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

IRS1 by KCNH2 expression — SKCM

Explore this box plot interactively →