KCNH2

Across TCGA cell cohorts, KCNH2 mutation is significantly associated with the RNA expression of many other genes, with 357 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNH2-associated genes across cancer lineages are C2orf42, YME1L1, and SCGB3A2. Each is linked with KCNH2 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNH2-to-partner and partner-to-KCNH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C2orf42 grouped by KCNH2-low versus KCNH2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH2→partner) and Y-score (partner→KCNH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C2orf42 →	+0.503	+2.491	<.001	.003	3	3
LARGE_INTESTINE	YME1L1 →	+0.462	+2.265	.004	.001	3	3
BLOOD_Leukemia	SCGB3A2 →	+0.064	+2.922	.001	.009	3	2
BLOOD_Leukemia	OR10K1 →	+0.272	+2.556	.008	.007	3	2
BLOOD_Leukemia	CCDC190 →	+0.032	+2.604	<.001	.006	3	2
BLOOD_Leukemia	OR1J2 →	+0.047	+2.669	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 357 associations by consensus.

C2orf42 by KCNH2 expression — LARGE_INTESTINE

Explore this box plot interactively →