KCNH1

Across TCGA patient cohorts, KCNH1 mutation is significantly associated with the RNA expression of many other genes, with 5,105 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNH1-associated genes across cancer lineages are ZWILCH, NDC80, and LIN52. Each is linked with KCNH1 in more than 4 cancer types. Because this analysis shows association rather than direction, both KCNH1-to-partner and partner-to-KCNH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZWILCH grouped by KCNH1-low versus KCNH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH1→partner) and Y-score (partner→KCNH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZWILCH →	+0.466	+1.740	<.001	<.001	3	5
UCEC	NDC80 →	+0.465	+1.523	.007	<.001	3	5
COAD	LIN52 →	+0.393	+2.013	<.001	.001	3	5
UCEC	WDHD1 →	+0.511	+1.523	<.001	<.001	3	4
UCEC	ARHGAP11A →	+0.571	+2.874	<.001	<.001	3	4
STAD	PSMA3 →	+0.426	+3.346	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,105 associations by consensus.

ZWILCH by KCNH1 expression — UCEC

Explore this box plot interactively →