KCNH1

Across TCGA cell cohorts, KCNH1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,645 significant associations in total. BONE shows the largest number of these associations.

The most reproducible KCNH1-associated GO terms across cancer lineages are Response to hyperoxia, Negative regulation of bone mineralization involved in bone maturation, and Regulation of cell-substrate junction organization. Each is linked with KCNH1 in more than 8 cancer types. Because this analysis shows association rather than direction, both KCNH1-to-partner and partner-to-KCNH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to hyperoxia grouped by KCNH1-low versus KCNH1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH1→partner) and Y-score (partner→KCNH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Response to hyperoxia →	+0.144	+0.789	<.001	.001	3	9
BONE	Negative regulation of bone mineralization involved in bone maturation →	+1.269	+1.086	<.001	.006	3	8
BONE	Regulation of cell-substrate junction organization →	+0.179	+1.200	<.001	.002	3	8
BONE	Regulation of cell-matrix adhesion →	+0.135	+0.972	<.001	.001	3	8
LIVER	Ventricular trabecula myocardium morphogenesis →	+0.233	+1.036	<.001	.006	3	8
LIVER	Positive regulation of establishment of T cell polarity →	+0.224	+0.763	.002	.008	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,645 associations by consensus.

Response to hyperoxia by KCNH1 expression — OVARY

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