KCNH1

Across TCGA cell cohorts, KCNH1 mutation is significantly associated with the RNA expression of many other genes, with 92 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNH1-associated genes across cancer lineages are DUXA, BHLHE23, and OR1L6. Each is linked with KCNH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNH1-to-partner and partner-to-KCNH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DUXA grouped by KCNH1-low versus KCNH1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNH1→partner) and Y-score (partner→KCNH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DUXA →	+0.025	+4.209	<.001	.006	3	2
BREAST	BHLHE23 →	+0.112	+4.781	<.001	.003	3	2
BONE	OR1L6 →	+0.020	+5.169	<.001	.004	3	1
BONE	C2orf80 →	+0.126	+5.169	<.001	.004	3	1
BONE	OR11G2 →	+0.013	+5.169	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR5A2 →	+0.002	+3.681	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 92 associations by consensus.

DUXA by KCNH1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →