KCNG1

Across TCGA patient cohorts, KCNG1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNG1-associated genes across cancer lineages are p27_pT198, Caspase-7-cleavedD198, and PKC-delta_pS664. Each is linked with KCNG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNG1-to-partner and partner-to-KCNG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by KCNG1-low versus KCNG1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNG1→partner) and Y-score (partner→KCNG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	p27_pT198 →	+0.196	+3.000	.004	.035	3	3
COAD	Caspase-7-cleavedD198 →	+1.605	+3.467	<.001	.002	3	3
STAD	PKC-delta_pS664 →	-0.146	-2.321	.016	.034	3	3
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.682	+2.000	.005	.031	3	3
COAD	Lck →	+0.334	+2.347	.015	.019	3	3
UCEC	EGFR_pY1068 →	-0.273	-2.807	.012	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

p27_pT198 by KCNG1 expression — LUAD

Explore this box plot interactively →