KCNF1

Across TCGA patient cohorts, KCNF1 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNF1-associated genes across cancer lineages are eEF2, PCNA, and Chk2_pT68. Each is linked with KCNF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNF1-to-partner and partner-to-KCNF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by KCNF1-low versus KCNF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNF1→partner) and Y-score (partner→KCNF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.461	+3.700	<.001	.001	3	3
UCEC	PCNA →	+0.303	+3.523	<.001	<.001	3	3
UCEC	Chk2_pT68 →	-0.134	-2.105	.040	.017	3	3
UCEC	ERK2 →	+0.180	+1.584	.008	.034	3	2
UCEC	GAPDH →	+0.458	+2.459	.015	.018	3	2
UCEC	IGFBP2 →	-0.491	-1.662	.032	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

eEF2 by KCNF1 expression — UCEC

Explore this box plot interactively →