KCNE5

Across TCGA cell cohorts, KCNE5 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KCNE5-associated genes across cancer lineages are NKX2-6, KRTAP21-2, and GUCA2A. Each is linked with KCNE5 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNE5-to-partner and partner-to-KCNE5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NKX2-6 grouped by KCNE5-low versus KCNE5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNE5→partner) and Y-score (partner→KCNE5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NKX2-6 →	+0.663	+5.201	<.001	.006	3	1
BLOOD_Leukemia	KRTAP21-2 →	+0.085	+5.539	<.001	.003	3	1
BLOOD_Leukemia	GUCA2A →	+0.052	+5.969	<.001	.001	3	1
BLOOD_Leukemia	FAM24A →	+0.082	+5.969	<.001	.001	3	1
BLOOD_Leukemia	IQCF5 →	+0.135	+5.201	<.001	.006	3	1
BLOOD_Leukemia	KRTAP7-1 →	+0.095	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

NKX2-6 by KCNE5 expression — BLOOD_Leukemia

Explore this box plot interactively →