KCNE4

Across TCGA pan-cancer cohorts, KCNE4 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KCNE4 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher KCNE4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KCNE4 expression acts as an unfavorable survival marker.

ACC, LUAD, and BLCA are the cancer types where KCNE4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	II,III,IV	0.145	0.872	<.001	37	view →
LUAD	OS	Median	III,IV	0.057	0.680	<.001	18	view →
BLCA	OS	Median	All	0.225	0.686	.047	6	view →
LIHC	DFS	Median	All	0.138	0.545	.006	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KCNE4–ACC (OS)

Open the ACC breakdown →