KCNE4

Across TCGA patient cohorts, KCNE4 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNE4-associated genes across cancer lineages are INPP4B, mTOR_pS2448, and Rab11. Each is linked with KCNE4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNE4-to-partner and partner-to-KCNE4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by KCNE4-low versus KCNE4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNE4→partner) and Y-score (partner→KCNE4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.309	-3.459	.020	.005	3	2
UCEC	mTOR_pS2448 →	-0.150	-2.308	.014	.033	3	2
COAD	Rab11 →	+0.166	+2.832	.048	.034	3	1
COAD	ATM →	-0.676	-2.991	<.001	.036	3	1
COAD	beta-Catenin →	-0.849	-2.991	.012	.036	3	1
UCEC	EGFR_pY1068 →	-0.224	-2.321	.030	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

INPP4B by KCNE4 expression — UCEC

Explore this box plot interactively →