KCND3-IT1

Across TCGA pan-cancer cohorts, KCND3-IT1 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated KCND3-IT1 data layer.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher KCND3-IT1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KCND3-IT1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and LIHC show a favorable association.

DLBC, LUSC, and READ are the cancer types where KCND3-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Tertile	II,III,IV	0.172	0.949	<.001	72	view →
LUSC	DFS	Tertile	III,IV	0.117	0.784	<.001	66	view →
READ	OS	Tertile	III,IV	0.257	0.756	<.001	54	view →
ESCA	OS	Tertile	III,IV	0.762	0.467	.006	27	view →
UVM	DFS	Tertile	All	0.186	0.786	<.001	27	view →
LIHC	OS	Tertile	III,IV	1.000	0.617	.002	15	view →
KIRP	DFS	Tertile	All	0.408	0.633	.001	12	view →
THYM	OS	Tertile	All	0.565	0.903	.018	6	view →
PAAD	DFS	Median	III,IV	0.893	0.470	.024	3	view →
LUAD	OS	Tertile	III,IV	0.841	0.455	.048	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

KCND3-IT1–DLBC (OS)

Open the DLBC breakdown →