KCNC4

Across TCGA patient cohorts, KCNC4 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNC4-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with KCNC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNC4-to-partner and partner-to-KCNC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by KCNC4-low versus KCNC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNC4→partner) and Y-score (partner→KCNC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.185	+1.514	.011	.015	3	2
COAD	Caspase-7-cleavedD198 →	+0.921	+2.824	.024	.034	3	2
UCEC	14-3-3_beta →	-0.079	-1.234	.021	.045	3	1
UCEC	EGFR →	-0.133	-1.848	.014	.049	3	1
UCEC	eIF4E →	+0.149	+3.183	.037	.009	3	1
UCEC	ERK2 →	+0.201	+2.502	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

PCNA by KCNC4 expression — UCEC

Explore this box plot interactively →