KCNC4

Across TCGA cell cohorts, KCNC4 mutation is significantly associated with the RNA expression of many other genes, with 193 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNC4-associated genes across cancer lineages are CBLIF, HES3, and PRORY. Each is linked with KCNC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNC4-to-partner and partner-to-KCNC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBLIF grouped by KCNC4-low versus KCNC4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNC4→partner) and Y-score (partner→KCNC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CBLIF →	+0.049	+4.643	<.001	.003	3	1
CNS	HES3 →	+0.043	+4.321	<.001	.009	3	1
CNS	PRORY →	+1.151	+5.044	<.001	.001	3	1
CNS	BTNL2 →	+0.034	+4.169	<.001	.008	3	1
CNS	OR2L8 →	+0.024	+4.754	<.001	.005	3	1
SKIN	EDDM3A →	+0.024	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 193 associations by consensus.

CBLIF by KCNC4 expression — CNS

Explore this box plot interactively →