KCNC2

Across TCGA patient cohorts, KCNC2 mutation is significantly associated with the total protein of many other genes, with 85 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNC2-associated genes across cancer lineages are FASN, FoxM1, and Cyclin-B1. Each is linked with KCNC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both KCNC2-to-partner and partner-to-KCNC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by KCNC2-low versus KCNC2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNC2→partner) and Y-score (partner→KCNC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FASN →	+0.398	+3.700	.045	.001	3	4
STAD	FoxM1 →	+0.321	+2.616	.001	.005	3	4
UCEC	Cyclin-B1 →	+0.660	+2.000	<.001	<.001	3	3
UCEC	PCNA →	+0.217	+2.321	.001	<.001	3	3
UCEC	TFRC →	+0.465	+3.807	.006	<.001	3	3
UCEC	Cyclin-E2 →	+0.135	+1.512	.013	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 85 associations by consensus.

FASN by KCNC2 expression — LUAD

Explore this box plot interactively →