KCNB1

Across TCGA cell cohorts, KCNB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,475 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KCNB1-associated GO terms across cancer lineages are Regulation of double-strand break repair via homologous recombination, Constitutive heterochromatin formation, and mRNA catabolic process. Each is linked with KCNB1 in more than 10 cancer types. Because this analysis shows association rather than direction, both KCNB1-to-partner and partner-to-KCNB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of double-strand break repair via homologous recombination grouped by KCNB1-low versus KCNB1-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNB1→partner) and Y-score (partner→KCNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Regulation of double-strand break repair via homologous recombination →	+0.056	+0.064	<.001	<.001	3	11
LARGE_INTESTINE	Constitutive heterochromatin formation →	+0.071	+0.071	<.001	.008	3	9
BLOOD_Leukemia	mRNA catabolic process →	+0.036	+0.079	<.001	.001	3	9
LUNG_NSCLC_LUAD	Secretion by tissue →	-0.142	-0.452	.005	.008	3	8
LUNG_SCLC	Negative regulation of telomere maintenance via telomere lengthening →	+0.061	+0.959	<.001	.002	3	8
LARGE_INTESTINE	Positive regulation of cation transmembrane transport →	-0.097	-0.091	<.001	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,475 associations by consensus.

Regulation of double-strand break repair via homologous recombination by KCNB1 expression — BLOOD_Leukemia

Explore this box plot interactively →