KCNB1

Across TCGA cell cohorts, KCNB1 mutation is significantly associated with the RNA expression of many other genes, with 1,060 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNB1-associated genes across cancer lineages are LUZP4, OR8B8, and GPR182. Each is linked with KCNB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNB1-to-partner and partner-to-KCNB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LUZP4 grouped by KCNB1-low versus KCNB1-high in LIVER.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNB1→partner) and Y-score (partner→KCNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	LUZP4 →	+0.096	+3.662	.008	.005	3	2
LUNG_SCLC	OR8B8 →	+0.038	+4.029	<.001	<.001	3	2
LARGE_INTESTINE	GPR182 →	+0.090	+2.478	.003	.006	3	2
LARGE_INTESTINE	SFTPB →	+0.165	+3.321	<.001	.004	3	2
BLOOD_Leukemia	GSG1L2 →	+0.028	+3.969	<.001	.009	3	2
LIVER	MARCHF11 →	+0.080	+3.584	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,060 associations by consensus.

LUZP4 by KCNB1 expression — LIVER

Explore this box plot interactively →