KCNAB3

Across TCGA patient cohorts, KCNAB3 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNAB3-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with KCNAB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNAB3-to-partner and partner-to-KCNAB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by KCNAB3-low versus KCNAB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNAB3→partner) and Y-score (partner→KCNAB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.269	+2.000	.003	.030	3	2
UCEC	Caspase-7-cleavedD198 →	+0.499	+2.341	.047	.019	3	2
UCEC	EGFR_pY1068 →	-0.217	-2.000	.041	.030	3	1
UCEC	eIF4E →	+0.189	+3.013	.035	.018	3	1
UCEC	ERK2 →	+0.222	+3.321	.006	.009	3	1
UCEC	JNK2 →	+0.284	+1.700	<.001	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

PCNA by KCNAB3 expression — UCEC

Explore this box plot interactively →