KCNAB1

Across TCGA patient cohorts, KCNAB1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNAB1-associated genes across cancer lineages are PI3K-p110-a, MEK1, and Notch1. Each is linked with KCNAB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNAB1-to-partner and partner-to-KCNAB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PI3K-p110-a grouped by KCNAB1-low versus KCNAB1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNAB1→partner) and Y-score (partner→KCNAB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PI3K-p110-a →	+0.183	+3.017	.010	.017	3	3
UCEC	MEK1 →	+0.354	+1.938	.003	.001	3	2
UCEC	Notch1 →	+0.135	+1.392	.003	.019	3	2
SKCM	AMPK_pT172 →	+0.381	+2.321	.012	.033	3	2
UCEC	Annexin-1 →	+0.424	+1.827	.014	.015	3	2
UCEC	TFRC →	+0.612	+3.087	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

PI3K-p110-a by KCNAB1 expression — SKCM

Explore this box plot interactively →