KCNA6

Across TCGA pan-cancer cohorts, KCNA6 Mutation is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated KCNA6 data layer compared with 1 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher KCNA6 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KCNA6 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

CESC, BLCA, and ACC are the cancer types where KCNA6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	III,IV	0.091	0.755	<.001	24	view →
BLCA	DFS	Median	All	1.000	0.325	.011	21	view →
ACC	DFS	Median	All	0.068	0.667	.005	12	view →
UCEC	DFS	Median	All	0.901	0.620	.014	8	view →
PAAD	OS	Median	All	0.131	0.640	.012	6	view →
PRAD	DFS	Median	All	0.160	0.886	<.001	6	view →
SARC	DFS	Median	All	0.121	0.613	.001	6	view →
LUAD	OS	Median	IV	0.153	0.714	.012	6	view →
LIHC	DFS	Median	II,III,IV	0.038	0.430	<.001	6	view →
HNSC	DFS	Median	All	1.000	0.317	.034	5	view →
SKCM	DFS	Median	II,III,IV	0.844	0.655	.008	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

KCNA6–CESC (OS)

Open the CESC breakdown →