KCNA6

Across TCGA patient cohorts, KCNA6 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNA6-associated genes across cancer lineages are Chk1, TFRC, and cIAP. Each is linked with KCNA6 in more than 3 cancer types. Because this analysis shows association rather than direction, both KCNA6-to-partner and partner-to-KCNA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk1 grouped by KCNA6-low versus KCNA6-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNA6→partner) and Y-score (partner→KCNA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	Chk1 →	+0.282	+3.035	.046	.017	3	3
UCEC	TFRC →	+0.376	+1.514	.005	.012	3	3
UCEC	cIAP →	+0.094	+1.196	.006	.002	3	3
COAD	PDCD4 →	-0.497	-2.991	.001	<.001	1	4
COAD	EGFR_pY1068 →	-0.249	-3.000	.041	.034	3	2
COAD	INPP4B →	-0.456	-3.584	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

Chk1 by KCNA6 expression — CESC

Explore this box plot interactively →