KCNA5

Across TCGA pan-cancer cohorts, KCNA5 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KCNA5 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher KCNA5 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated KCNA5 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ESCA, STAD, and LGG are the cancer types where KCNA5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	All	0.197	0.545	<.001	24	view →
STAD	OS	Median	III,IV	0.111	0.642	<.001	9	view →
LGG	DFS	Median	All	0.080	0.826	<.001	6	view →
UCEC	DFS	Median	All	0.922	0.827	.041	4	view →
COAD	DFS	Median	IV	0.035	0.501	<.001	3	view →
SKCM	OS	Median	II,III,IV	0.202	0.731	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KCNA5–ESCA (DFS)

Open the ESCA breakdown →