KCNA5

Across TCGA patient cohorts, KCNA5 mutation is significantly associated with the total protein of many other genes, with 84 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNA5-associated genes across cancer lineages are C-Raf, FoxM1, and GAPDH. Each is linked with KCNA5 in more than 4 cancer types. Because this analysis shows association rather than direction, both KCNA5-to-partner and partner-to-KCNA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by KCNA5-low versus KCNA5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNA5→partner) and Y-score (partner→KCNA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.143	+1.754	<.001	<.001	3	5
LUAD	FoxM1 →	+0.232	+2.334	.026	.018	3	4
COAD	GAPDH →	+0.427	+3.169	.027	.017	3	4
STAD	TFRC →	+0.812	+3.000	.011	.036	3	4
UCEC	Cyclin-B1 →	+0.563	+1.584	<.001	<.001	3	4
SKCM	eEF2 →	+0.395	+2.459	.012	.020	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

C-Raf by KCNA5 expression — UCEC

Explore this box plot interactively →