KCNA5

Across TCGA cell cohorts, KCNA5 mutation is significantly associated with the RNA expression of many other genes, with 48 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNA5-associated genes across cancer lineages are G6PC2, PIP, and OR1L4. Each is linked with KCNA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNA5-to-partner and partner-to-KCNA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, G6PC2 grouped by KCNA5-low versus KCNA5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNA5→partner) and Y-score (partner→KCNA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	G6PC2 →	+0.029	+2.584	<.001	.001	3	2
BLOOD_Myeloma	PIP →	+0.040	+4.807	<.001	.006	3	1
URINARY_TRACT	OR1L4 →	+0.060	+4.087	<.001	.009	3	1
URINARY_TRACT	FABP9 →	+0.042	+4.087	<.001	.009	3	1
OESOPHAGUS	HMGB4 →	+0.043	+4.906	<.001	.006	3	1
CNS	IL21 →	+0.038	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

G6PC2 by KCNA5 expression — LARGE_INTESTINE

Explore this box plot interactively →