KCNA4

Across TCGA cell cohorts, KCNA4 mutation is significantly associated with the RNA expression of many other genes, with 752 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNA4-associated genes across cancer lineages are MAGEB5, PIRT, and SCN1A. Each is linked with KCNA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNA4-to-partner and partner-to-KCNA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by KCNA4-low versus KCNA4-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNA4→partner) and Y-score (partner→KCNA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	PIRT →	+0.006	+4.643	<.001	.008	3	1
BLOOD_Leukemia	SCN1A →	+0.511	+4.404	<.001	<.001	3	1
BLOOD_Leukemia	CPXCR1 →	+0.081	+3.971	<.001	.002	3	1
BLOOD_Leukemia	OR1N1 →	+0.075	+3.234	<.001	.008	3	1
BLOOD_Leukemia	PRND →	+0.007	+3.289	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 752 associations by consensus.

MAGEB5 by KCNA4 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →