KCNA2

Across TCGA pan-cancer cohorts, KCNA2 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated KCNA2 data layer compared with 21 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KCNA2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KCNA2 expression acts as an unfavorable survival marker.

HNSC, SCLC, and SKCM are the cancer types where KCNA2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.100	0.711	<.001	42	view →
SCLC	OS	Median	All	0.178	0.714	<.001	12	view →
SKCM	OS	Median	All	0.377	0.789	.004	11	view →
LIHC	DFS	Median	II,III,IV	0.077	0.463	.002	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LUAD	OS	Median	All	0.384	0.680	.021	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
LUSC	DFS	Median	All	0.064	0.791	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

KCNA2–HNSC (OS)

Open the HNSC breakdown →