KCNA2

Across TCGA patient cohorts, KCNA2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNA2-associated genes across cancer lineages are EGFR_pY1068, IGFBP2, and RAD51. Each is linked with KCNA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNA2-to-partner and partner-to-KCNA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by KCNA2-low versus KCNA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNA2→partner) and Y-score (partner→KCNA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.352	-3.584	<.001	.002	3	2
UCEC	IGFBP2 →	-0.591	-2.459	.027	.019	3	2
UCEC	RAD51 →	+0.127	+2.999	.027	.035	3	2
UCEC	Annexin-1 →	+0.663	+1.604	.002	.041	3	2
UCEC	ARID1A →	-0.162	-2.108	.042	.018	3	2
UCEC	VEGFR2 →	+0.386	+1.884	.001	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

EGFR_pY1068 by KCNA2 expression — UCEC

Explore this box plot interactively →