KCNA2

Across TCGA cell cohorts, KCNA2 mutation is significantly associated with the drug of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCNA2-associated genes across cancer lineages are LCL161, ULK1_4989, and Quizartinib. Each is linked with KCNA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNA2-to-partner and partner-to-KCNA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCL161 grouped by KCNA2-low versus KCNA2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNA2→partner) and Y-score (partner→KCNA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LCL161 →	+0.345	+2.646	.034	.047	3	1
LARGE_INTESTINE	ULK1_4989 →	+0.686	+2.649	.038	.046	3	1
LARGE_INTESTINE	Quizartinib →	+0.368	+2.652	.022	.045	3	1
LARGE_INTESTINE	729189 →	+0.285	+2.649	.025	.046	2	1
LARGE_INTESTINE	Nutlin-3a (-) →	+0.781	+2.646	.033	.047	1	1
LARGE_INTESTINE	IAP_5620 →	+0.378	+2.649	.040	.046	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

LCL161 by KCNA2 expression — LARGE_INTESTINE

Explore this box plot interactively →