KCNA1

Across TCGA pan-cancer cohorts, KCNA1 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated KCNA1 data layer compared with 27 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher KCNA1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KCNA1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

OV, SCLC, and ESCA are the cancer types where KCNA1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.082	0.844	<.001	36	view →
SCLC	OS	Median	All	0.082	0.708	<.001	36	view →
ESCA	DFS	Median	All	0.272	0.551	.003	30	view →
KIRC	OS	Median	All	0.134	0.811	<.001	28	view →
UCEC	DFS	Median	II,III,IV	0.751	0.553	.006	28	view →
LIHC	OS	Median	III,IV	0.111	0.656	<.001	24	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
LAML	DFS	Median	All	0.111	0.572	.010	12	view →
CESC	OS	Median	IV	0.091	0.593	<.001	12	view →
BLCA	OS	Median	III,IV	0.202	0.592	.001	12	view →
SKCM	DFS	Median	III,IV	0.087	0.647	.013	6	view →
LGG	DFS	Median	All	0.555	0.826	.013	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

KCNA1–OV (OS)

Open the OV breakdown →