KCMF1

Across TCGA patient cohorts, KCMF1 mutation is significantly associated with the RNA expression of many other genes, with 1,471 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCMF1-associated genes across cancer lineages are MIR4445, ALDOA, and NOCT. Each is linked with KCMF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCMF1-to-partner and partner-to-KCMF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4445 grouped by KCMF1-low versus KCMF1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCMF1→partner) and Y-score (partner→KCMF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR4445 →	+0.326	+7.731	<.001	.009	3	2
UCEC	ALDOA →	+0.490	+3.807	.002	<.001	3	2
UCEC	NOCT →	+0.851	+2.917	<.001	<.001	3	2
UCEC	ATP5F1A →	+0.443	+2.190	.003	.008	3	2
UCEC	SKA1 →	+0.620	+2.606	.001	.005	3	2
UCEC	SEC13 →	+0.362	+2.362	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,471 associations by consensus.

MIR4445 by KCMF1 expression — BRCA

Explore this box plot interactively →