KCMF1

Across TCGA patient cohorts, KCMF1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCMF1-associated genes across cancer lineages are Caspase-7-cleavedD198, INPP4B, and MEK1. Each is linked with KCMF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCMF1-to-partner and partner-to-KCMF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by KCMF1-low versus KCMF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCMF1→partner) and Y-score (partner→KCMF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.638	+2.019	.006	.017	3	2
UCEC	INPP4B →	-0.315	-2.700	.013	.006	3	1
UCEC	MEK1 →	+0.360	+2.000	.012	.010	3	1
UCEC	MSH6 →	-0.360	-2.459	.005	.018	3	1
UCEC	Notch1 →	+0.148	+1.584	.007	.036	3	1
UCEC	PCNA →	+0.248	+2.000	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Caspase-7-cleavedD198 by KCMF1 expression — UCEC

Explore this box plot interactively →