KBTBD8

Across TCGA pan-cancer cohorts, KBTBD8 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of KBTBD8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KBTBD8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KBTBD8 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

KIRC, HNSC, and LUSC are the cancer types where KBTBD8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KBTBD8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.488	<.001	11	view →
HNSC	All	All	+0.350	.002	8	view →
LUSC	Female	All	−1.059	<.001	7	view →
LUAD	All	II,III,IV	−0.489	<.001	7	view →
BLCA	Female	III,IV	−1.205	.003	6	view →
THCA	Female	All	−0.668	<.001	4	view →
STAD	Female	All	+0.937	.003	2	view →
BRCA	Female	II,III,IV	+0.151	.041	2	view →
ESCA	All	All	+0.361	.045	1	view →
LIHC	All	III,IV	+0.263	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

KBTBD8–KIRC

Open the KIRC breakdown →