KBTBD7

Across TCGA pan-cancer cohorts, KBTBD7 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KBTBD7 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KBTBD7 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KBTBD7 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where KBTBD7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.352	0.902	.004	49	view →
LUAD	DFS	Tertile	III,IV	0.253	1.000	.024	6	view →
PDAC	OS	Median	II,III,IV	0.793	0.174	.024	6	view →
LSCC	OS	Median	II,III,IV	0.895	0.563	.010	2	view →
GBM	DFS	Tertile	All	0.825	0.622	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KBTBD7–HNSC (DFS)

Open the HNSC breakdown →