KBTBD7

Across TCGA patient cohorts, KBTBD7 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KBTBD7-associated genes across cancer lineages are PCNA, C-Raf, and eIF4E. Each is linked with KBTBD7 in more than 2 cancer types. Because this analysis shows association rather than direction, both KBTBD7-to-partner and partner-to-KBTBD7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by KBTBD7-low versus KBTBD7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KBTBD7→partner) and Y-score (partner→KBTBD7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.228	+1.874	<.001	.002	3	3
UCEC	C-Raf →	+0.109	+1.362	.014	.034	3	3
UCEC	eIF4E →	+0.132	+1.415	.043	.010	3	2
UCEC	INPP4B →	-0.220	-1.502	.028	.025	3	2
UCEC	Notch1 →	+0.128	+1.594	.003	.010	3	2
UCEC	PRDX1 →	+0.135	+1.584	.034	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

PCNA by KBTBD7 expression — UCEC

Explore this box plot interactively →