KBTBD6

Across TCGA patient cohorts, KBTBD6 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KBTBD6-associated genes across cancer lineages are EGFR_pY1068, EGFR_pY1173, and mTOR_pS2448. Each is linked with KBTBD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both KBTBD6-to-partner and partner-to-KBTBD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by KBTBD6-low versus KBTBD6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KBTBD6→partner) and Y-score (partner→KBTBD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.190	-2.321	.039	.033	3	2
UCEC	EGFR_pY1173 →	+0.069	+1.529	.018	.018	3	2
UCEC	mTOR_pS2448 →	-0.126	-2.446	.021	.018	3	2
UCEC	Notch1 →	+0.174	+2.125	<.001	.010	3	2
UCEC	PCNA →	+0.191	+1.502	.016	.030	3	2
UCEC	TFRC →	+0.563	+3.807	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

EGFR_pY1068 by KBTBD6 expression — UCEC

Explore this box plot interactively →