KBTBD3

Across TCGA pan-cancer cohorts, KBTBD3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KBTBD3 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher KBTBD3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KBTBD3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, HNSC, and GBM are the cancer types where KBTBD3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	1.000	0.517	.001	38	view →
HNSC	OS	Median	All	0.658	0.863	.013	20	view →
GBM	OS	Median	All	0.623	0.449	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

KBTBD3–LSCC (DFS)

Open the LSCC breakdown →