KBTBD3

Across TCGA patient cohorts, KBTBD3 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KBTBD3-associated genes across cancer lineages are Lck, MEK1, and p38-MAPK_pT180_Y182. Each is linked with KBTBD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KBTBD3-to-partner and partner-to-KBTBD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by KBTBD3-low versus KBTBD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KBTBD3→partner) and Y-score (partner→KBTBD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.197	+1.362	.005	.037	3	2
UCEC	MEK1 →	+0.330	+1.362	.010	.037	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.498	-2.000	.001	.009	3	2
UCEC	Src_pY527 →	-0.475	-2.311	.001	.005	3	2
UCEC	Transglutaminase →	+0.408	+1.700	.010	.042	3	2
UCEC	4E-BP1_pT37_T46 →	-0.284	-1.687	.032	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Lck by KBTBD3 expression — UCEC

Explore this box plot interactively →