Across TCGA patient cohorts, KBTBD12 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KBTBD12-associated genes across cancer lineages are PKC-b-II_pS660, Annexin-1, and MEK1. Each is linked with KBTBD12 in more than 2 cancer types. Because this analysis shows association rather than direction, both KBTBD12-to-partner and partner-to-KBTBD12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KBTBD12→partner) and Y-score (partner→KBTBD12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-b-II_pS660 →	-0.213	-1.678	.044	.023	3	3
SKCM	Annexin-1 →	+0.647	+2.459	.001	.018	3	2
UCEC	MEK1 →	+0.577	+3.247	<.001	<.001	3	2
UCEC	TFRC →	+0.668	+2.584	.001	.001	3	2
UCEC	ASNS →	+0.331	+2.321	.016	.034	3	2
UCEC	ATM →	-0.740	-3.700	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Exploration

KBTBD12 survival (RNA) · tumor vs normal (RNA) · all KBTBD12 data types