KAZALD1

Across TCGA patient cohorts, KAZALD1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KAZALD1-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and Dvl3. Each is linked with KAZALD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KAZALD1-to-partner and partner-to-KAZALD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by KAZALD1-low versus KAZALD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KAZALD1→partner) and Y-score (partner→KAZALD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.372	+3.000	.017	.037	3	1
UCEC	Cyclin-B1 →	+0.867	+3.000	.007	.037	3	1
UCEC	Dvl3 →	+0.253	+3.000	.017	.037	3	1
UCEC	EGFR_pY1068 →	-0.286	-3.000	.049	.037	2	1
UCEC	Shc_pY317 →	-0.238	-3.000	.006	.037	2	1
UCEC	p70-S6K →	+0.229	+3.026	.040	.019	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

4E-BP1 by KAZALD1 expression — UCEC

Explore this box plot interactively →