KATNIP

Across TCGA pan-cancer cohorts, KATNIP mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KATNIP data layer compared with 22 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher KATNIP mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated KATNIP expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where KATNIP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.534	1.000	.003	41	view →
CCRCC	OS	Median	All	0.545	1.000	.014	14	view →
HNSC	OS	Tertile	II,III,IV	0.921	1.000	.029	6	view →
UCEC	DFS	Median	All	0.954	0.858	.022	2	view →
GBM	OS	Quartile	All	0.666	0.852	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KATNIP–PDAC (OS)

Open the PDAC breakdown →