KATNIP

Across TCGA patient cohorts, KATNIP mutation is significantly associated with the RNA expression of many other genes, with 5,548 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KATNIP-associated genes across cancer lineages are EME1, CDCA2, and SKA1. Each is linked with KATNIP in more than 5 cancer types. Because this analysis shows association rather than direction, both KATNIP-to-partner and partner-to-KATNIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EME1 grouped by KATNIP-low versus KATNIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KATNIP→partner) and Y-score (partner→KATNIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EME1 →	+0.580	+1.928	<.001	<.001	3	6
UCEC	CDCA2 →	+0.684	+2.129	<.001	<.001	3	6
COAD	SKA1 →	+0.717	+3.100	<.001	<.001	3	5
LUAD	CHAF1B →	+0.662	+3.807	.001	<.001	3	5
UCEC	TRUB2 →	+0.338	+1.583	<.001	<.001	3	5
UCEC	RFC2 →	+0.371	+1.765	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,548 associations by consensus.

EME1 by KATNIP expression — UCEC

Explore this box plot interactively →