KATNIP

Across TCGA cell cohorts, KATNIP mutation is significantly associated with the RNA expression of many other genes, with 644 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KATNIP-associated genes across cancer lineages are DEFB124, FAM71C, and UNC45B. Each is linked with KATNIP in more than 1 cancer types. Because this analysis shows association rather than direction, both KATNIP-to-partner and partner-to-KATNIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB124 grouped by KATNIP-low versus KATNIP-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KATNIP→partner) and Y-score (partner→KATNIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DEFB124 →	+0.097	+2.658	<.001	.004	3	2
BLOOD_Lymphoma	FAM71C →	+0.023	+3.714	<.001	.006	3	2
LUNG_SCLC	UNC45B →	+0.008	+3.256	<.001	.005	3	2
LARGE_INTESTINE	TLE6 →	+0.946	+3.295	<.001	.003	3	2
LARGE_INTESTINE	UFSP2 →	+0.622	+2.628	<.001	.002	3	2
LARGE_INTESTINE	ATAD1 →	+0.457	+2.714	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 644 associations by consensus.

DEFB124 by KATNIP expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →