KATNBL1

Across TCGA patient cohorts, KATNBL1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KATNBL1-associated genes across cancer lineages are BRD4, 14-3-3_beta, and EGFR_pY1068. Each is linked with KATNBL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KATNBL1-to-partner and partner-to-KATNBL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRD4 grouped by KATNBL1-low versus KATNBL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KATNBL1→partner) and Y-score (partner→KATNBL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BRD4 →	+0.262	+3.584	.007	.002	3	2
UCEC	14-3-3_beta →	-0.078	-2.295	.031	.033	3	1
UCEC	EGFR_pY1068 →	-0.242	-1.925	.007	.005	3	1
UCEC	A-Raf_pS299 →	-0.163	-2.321	<.001	.005	3	1
UCEC	FoxM1 →	+0.227	+1.710	.015	.025	3	1
UCEC	ACC1 →	+0.355	+1.925	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

BRD4 by KATNBL1 expression — UCEC

Explore this box plot interactively →