KATNAL1

Across TCGA patient cohorts, KATNAL1 mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KATNAL1-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, Src_pY527, and 4E-BP1. Each is linked with KATNAL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KATNAL1-to-partner and partner-to-KATNAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by KATNAL1-low versus KATNAL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KATNAL1→partner) and Y-score (partner→KATNAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.437	+1.765	.021	.014	3	2
UCEC	Src_pY527 →	-0.481	-2.459	.002	.018	3	2
UCEC	4E-BP1 →	+0.301	+2.489	.002	.010	3	2
UCEC	eEF2 →	+0.334	+1.415	.012	.046	3	1
UCEC	EGFR_pY1068 →	-0.314	-3.700	<.001	.001	3	1
UCEC	eIF4E →	+0.156	+2.335	.049	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

Acetyl-a-Tubulin-Lys40 by KATNAL1 expression — UCEC

Explore this box plot interactively →