KAT8

Across TCGA pan-cancer cohorts, KAT8 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KAT8 data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher KAT8 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated KAT8 expression acts as an unfavorable survival marker.

THCA, KIRP, and UCEC are the cancer types where KAT8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Median	All	0.095	0.896	<.001	18	view →
KIRP	OS	Median	All	0.135	0.703	.002	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

KAT8–THCA (DFS)

Open the THCA breakdown →