KAT8

Across TCGA pan-cancer cohorts, KAT8 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KAT8 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KAT8 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated KAT8 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where KAT8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.134	1.000	.008	47	view →
LSCC	DFS	Quartile	II,III,IV	0.883	0.402	.006	33	view →
CCRCC	OS	Tertile	III,IV	0.772	0.384	.004	28	view →
LUAD	OS	Tertile	II,III,IV	0.868	0.311	.007	9	view →
GBM	DFS	Quartile	All	0.433	0.259	.017	5	view →
PDAC	DFS	Tertile	IV	0.752	0.203	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KAT8–HNSC (OS)

Open the HNSC breakdown →